藤里俊哉 | 研究・メンバー紹介 | 地域産業支援プラットフォーム OIT-P

藤里俊哉

技術イノベーション拠点
デバイス開発（生体）グループ

工学部生命工学科教授

◆ これまでの代表的な外部資金獲得実績

1) 三次元培養筋を活用した骨格筋の新たな生理的機能の解明．科研費基盤研究(C)、2017～2019年度、総額 4,680,000円、分担者（代表者大阪工業大学中村友浩）
2) 組織工学技術を用いたバイオ筋肉モジュールの開発．科研費基盤研究(C)、2016～2018年度、総額 4,680,000円、代表者
3) 動物繊維から作成するナノファイバー再生繊維の評価と生体材料への応用．科研費基盤研究(C)、2015～2017年度、総額 4,940,000円、分担者（代表者大阪成蹊短期大学澤田和也）
4) 先天性巨大色素性母斑を母地とした悪性黒色腫に対する予防的低侵襲治療方法の開発．AMED革新的がん医療実用化研究事業、2014～2016年度、総額 69,000,000円、分担者（関西医科大学森本尚樹）
5) ３次元培養筋を用いた筋収縮依存的に発現する遺伝子群の網羅的解析．科研費基盤研究(C)、2013～2015年度、総額 4,940,000円、分担者（代表者大阪工業大学中村友浩）
6) 生体組織構築技術を用いたバイオ人工筋肉の開発．科研費基盤研究(C)、2012～2015年度、総額 5,200,000円、代表者
7) 脱細胞小口径血管の早期内皮化処理と長期開存性の達成．科研費基盤研究(B)、2012～2014年度、総額 18,200,000円、分担者（代表者国立循環器病研究センター中谷武嗣）
8) 腫瘍細胞を含む切除組織からの脱細胞化および再移植方法の検討．科研費挑戦的萌芽研究、2012～2013年度、総額 3,640,000円、分担者（代表者関西医科大学森本尚樹）

◆ 最近の主な研究業績

1) Takagi S, Nakamura T, Fujisato T. Effect of heat stress on contractility of tissue-engineered artificial skeletal muscle. J Artif Organs 2018; ;21(2): 207-214.
2) Morimoto N, Mahara A, Jinno C, Ogawa M, Kakudo N, Suzuki S, Fujisato T, Kusumoto K, Yamaoka T. The superiority of the autografts inactivated by high hydrostatic pressure to decellularized allografts in a porcine model. J Biomed Mater Res B Appl Biomater. 2017; 105(8): 2653-2661.
3) Nakamura T, Takagi S, Kamon T, Yamasaki KI, Fujisato T. Development and evaluation of a removable tissue-engineered muscle with artificial tendons. J Biosci Bioeng. 2017; 123(2): 265-271.
4) Morimoto N, Mahara A, Jinno C, Ogawa M, Kakudo N, Suzuki S, Kusumoto K, Fujisato T, Yamaoka T. An evaluation of the engraftment and the blood flow of porcine skin autografts inactivated by high hydrostatic pressure. J Biomed Mater Res B Appl Biomater. 2017; 105(5): 1091-1101.
5) Morimoto N, Jinno C, Mahara A, Sakamoto M, Kakudo N, Inoie M, Fujisato T, Suzuki S, Kusumoto K, Yamaoka T. The Alteration of the Epidermal Basement Membrane Complex of Human Nevus Tissue and Keratinocyte Attachment after High Hydrostatic Pressurization. Biomed Res Int. 2016; 2016: 1320909.
6) Morimoto N, Jinno C, Mahara A, Kakudo N, Fujisato T, Kusumoto K, Suzuki S, Yamaoka T. Verification of the Inactivation of Melanocytic Nevus in vitro Using a Newly Developed Portable High Hydrostatic Pressure Device. Cells Tissues Organs. 2016; 201(3): 170-9.
7) Liem PH, Morimoto N, Mahara A, Jinno C, Shima K, Ogino S, Sakamoto M, Kakudo N, Inoie M, Kusumoto K, Fujisato T, Suzuki S, Yamaoka T. Preparation of Inactivated Human Skin Using High Hydrostatic Pressurization for Full-Thickness Skin Reconstruction. PLoS One. 2015; 10(7): e0133979.
8) Jinno C, Morimoto N, Mahara A, Liem PH, Sakamoto M, Ogino S, Kakudo N, Inoie M, Fujisato T, Kusumoto K, Suzuki S, Yamaoka T. Inactivation of Human Nevus Tissue Using High Hydrostatic Pressure for Autologous Skin Reconstruction: A Novel Treatment for Giant Congenital Melanocytic Nevi. Tissue Eng Part C Methods. 2015; 21(11): 1178-87.
9) Kakinoki S, Sakai Y, Fujisato T, Yamaoka T. Accelerated tissue integration into porous materials by immobilizing basic fibroblast growth factor using a biologically safe three-step reaction. J Biomed Mater Res A. 2015; 103(12): 3790-7.13.
10) Wu P, Nakamura N, Kimura T, Nam K, Fujisato T, Funamoto S, Higami T, Kishida A. Decellularized porcine aortic intima-media as a potential cardiovascular biomaterial. Interact Cardiovasc Thorac Surg. 2015; 21(2): 189-94.
11) Mahara A, Somekawa S, Kobayashi N, Hirano Y, Kimura Y, Fujisato T, Yamaoka T. Tissue-engineered acellular small diameter long-bypass grafts with neointima-inducing activity. Biomaterials. 2015; 58: 54-62.
12) Morimoto N, Mahara A, Shima K, Ogawa M, Jinno C, Kakudo N, Kusumoto K, Fujisato T, Suzuki S, Yamaoka T. The rapid inactivation of porcine skin by applying high hydrostatic pressure without damaging the extracellular matrix. Biomed Res Int. 2015: 587247.
13) Ishino N, Fujisato T. Decellularization of porcine carotid by the recipient's serum and evaluation of its biocompatibility using a rat autograft model. J Artif Organs. 2015; 18(2): 136-42.
14) Mahara A, Sago M, Yamaguchi H, Ehashi T, Minatoya K, Tanaka H, Nakatani T, Moritan T, Fujisato T, Yamaoka T. Micro-CT evaluation of high pressure-decellularized cardiovascular tissues transplanted in rat subcutaneous accelerated-calcification model. J Artif Organs. 2015; 18(2): 143-50.
15) Wu P, Kimura T, Tadokoro H, Nam K, Fujisato T, Kishida A. Relation between the tissue structure and protein permeability of decellularized porcine aorta. Mater Sci Eng C Mater Biol Appl. 2014; 43: 465-71.
16) Kakinoki S, Sakai Y, Takemura T, Hanagata N, Fujisato T, Ishihara K, Yamaoka T. Gene chip/PCR-array analysis of tissue response to 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer surfaces in a mouse subcutaneous transplantation system. J Biomater Sci Polym Ed. 2014; 25(14-15): 1658-72.
17) Nam K, Matsushima R, Kimura T, Fujisato T, Kishida A. In vivo characterization of a decellularized dermis-polymer complex for use in percutaneous devices. Artif Organs. 2014; 38(12): 1060-5.
18) Mahara A, Morimoto N, Sakuma T, Fujisato T, Yamaoka T. Complete cell killing by applying high hydrostatic pressure for acellular vascular graft preparation. Biomed Res Int. 2014; 2014: 379607.
19) Nagaoka Y, Yamada H, Kimura T, Kishida A, Fujisato T, Takakuda K. Reconstruction of small diameter arteries using decellularized vascular scaffolds. J Med Dent Sci. 2014; 61(1): 33-40.
20) Negishi J, Nam K, Kimura T, Hashimoto Y, Funamoto S, Higami T, Fujisato T, Kishida A. Fabrication of a heparin-PVA complex hydrogel for application as a vascular access. J Biomed Mater Res B Appl Biomater. 2014; 102(7): 1426-33.

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